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国内团队:地中海饮食或可预防结直肠癌

创作:Vicky审核:何才高2020-08-04

①纳入13项前瞻性队列研究进行荟萃分析;

②相比于地中海饮食依从性最低的受试者,地中海饮食依从性最高的受试者的结直肠癌发病风险显著降低,相对风险为0.90;

③其中,直肠癌相对风险为0.82,近端结肠癌相对风险为0.94,远端结肠癌相对风险为0.91;

④地中海饮食依从性评分每升高2分,结直肠癌发病风险显著降低,相对风险为0.96;

⑤地中海饮食依从性与结直肠癌患者的总死亡率及结直肠癌死亡率无显著关联。


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来自南京医科大学第二附属医院的缪林团队与金陵医院的周光新团队在American Journal of Clinical Nutrition上发表的一项荟萃分析结果,对13项前瞻性队列研究的结果进行总结后发现,地中海饮食依从性越高,结直肠癌发病风险越低,但地中海饮食与结直肠癌患者的死亡率无显著关联。

延伸导读

本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
American Journal of Clinical Nutrition
[IF:6.766]
Association between Mediterranean diet adherence and colorectal cancer: a dose-response meta-analysis
地中海饮食依从性与结直肠癌风险之间的关联:剂量效应荟萃分析
10.1093/ajcn/nqaa083
05-02, Article
Abstract:
Background: Mounting epidemiologic studies have investigated the potential inverse association between Mediterranean diet (MD) adherence and colorectal cancer (CRC) incidence and mortality.
Objectives: This meta‐analysis aimed to investigate the association between MD adherence and CRC incidence and mortality. Methods: PubMed, Embase, and Web of Science were searched to identify eligible studies through September 2019. A random-effects model was used to estimate summary RRs and 95% CIs.
Results: This meta-analysis included 13 prospective cohort studies, of which 9 reported CRC incidence and 5 reported CRC mortality. The summary RR of CRC incidence was 0.90 (95% CI: 0.84, 0.96) for highest compared with lowest MD adherence and 0.96 (95% CI: 0.94, 0.99) per 2-score increase in MD adherence. The summary RRs for highest compared with lowest MD adherence were 0.82 for rectal cancer (95% CI: 0.71, 0.95), 0.94 for proximal colon cancer (95% CI: 0.87, 1.02), and 0.91 for distal colon cancer (95% CI: 0.79, 1.04). Neither the summary HR of overall mortality for highest compared with lowest pre- and postdiagnosis MD adherence, nor the summary HR of CRC-specific mortality for highest compared with lowest prediagnosis MD adherence achieved a value with statistical significance.
Conclusions: Our meta-analysis supports the inverse association of MD adherence with CRC incidence, but not with overall mortality or CRC-specific mortality among those diagnosed with CRC.