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午后易走神?或许要怪饱和脂肪吃太多

创作:Vicky审核:何才高2020-07-31

①纳入51名女性进行一项双盲随机交叉试验,在高饱和脂肪餐或高不饱和脂肪餐前1小时和餐后5小时完成持续性操作试验(CPT);

②与吃高不饱和脂肪餐相比,吃高饱和脂肪餐的女性在餐后的分辨目标能力降低;

③LPS结合蛋白(LBP)及LBP:可溶性CD14(sCD14)比值较高的女性,在整个CPT中保持注意力的能力较弱;

④基线LBP或sCD14较高的女性,在较高的刺激间隔内维持或增加反应速度的能力较弱;

⑤无论进餐类型如何,内毒素血症都会损害餐后注意力。


关键词

主编推荐语

饱和脂肪和内毒素血症可损伤认知功能,但偶尔吃一顿高饱和脂肪餐会不会影响认知功能呢?《American Journal of Clinical Nutrition》近期发表的一项临床试验,探究了食用高饱和脂肪餐或高不饱和脂肪餐(富含油酸葵花油)对餐后注意力的影响。研究结果显示,高饱和脂肪餐不利于午后注意力集中。这与体内的内毒素血症标志物LBP和sCD14的浓度水平,以及LBP与sCD14的比值有关。

延伸导读

本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
American Journal of Clinical Nutrition
[IF:6.766]
Afternoon distraction: a high-saturated-fat meal and endotoxemia impact postmeal attention in a randomized crossover trial
午后注意力分散:一项随机交叉试验中高饱和脂肪餐和内毒素血症影响餐后注意力
10.1093/ajcn/nqaa085
05-12, Article
Abstract:
Background: Saturated-fat intake and endotoxemia can impair cognition. However, their acute impact on cognitive performance is unknown.
Objective: This study assessed the impact of 2 high-fat meals and endotoxemia on attention. Methods: In this double-blind, randomized crossover trial, 51 women (n = 32 breast cancer survivors, n = 19 noncancer controls; mean ± SD age: 53 ± 8 y) completed the Continuous Performance Test (CPT) and had their blood drawn to assess endotoxemia markers LPS binding protein (LBP), soluble CD14 (sCD14), and the LBP to sCD14 ratio 1 h prior to eating either a high-saturated-fat meal or a high-oleic-sunflower-oil meal. Women again completed the CPT 5 h postmeal. At 1 to 4 wk later, women completed the same protocol but consumed the other meal.
Results: In adjusted models, women had more difficulty distinguishing target stimuli from distractors after consuming the high-saturated-fat meal than they did after the oleic-sunflower-oil meal (B = 4.44, SE = 1.88, P = 0.02). Women with higher baseline LBP had less consistent response times (B = 0.002, SE = 0.0008, P = 0.04). Those with higher LBP and LBP:sCD14 were less able to sustain their attention throughout the entire CPT, as reflected by their progressively slower (B = 0.002, SE = 0.0006, P = 0.003; and B = 2.43, SE = 0.090, P = 0.008, respectively) and more erratic (B = 0.003, SE = 0.0008, P < 0.0001; and B = 3.29, SE = 1.17, P = 0.006, respectively) response times. Additionally, women with higher baseline LBP or sCD14 were less able to maintain or increase response speeds at higher interstimulus intervals (B = 0.002, SE = 0.0006, P = 0.02; and B = 0.006, SE = 0.003, P = 0.03, respectively), indicating greater difficulty adapting to changing task demands. Significant meal type by LBP and LBP:sCD14 interactions emerged (P < 0.05), such that high LBP and LBP:sCD14 erased between-meal cognitive differences, uniformly impairing performance.
Conclusions: These results suggest that higher LBP, sCD14, and LBP:sCD14 and saturated-fat intake individually and jointly influence attention. Endotoxemia may override the relative cognitive benefit of healthier oil choices.